Evidence That Extrapancreatic GLUT2-Dependent Glucose Sensors Control Glucagon Secretion
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چکیده
منابع مشابه
Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion.
GLUT2-/- mice reexpressing GLUT1 or GLUT2 in their beta-cells (RIPGLUT1 x GLUT2-/- or RIPGLUT2 x GLUT2-/- mice) have nearly normal glucose-stimulated insulin secretion but show high glucagonemia in the fed state. Because this suggested impaired control of glucagon secretion, we set out to directly evaluate the control of glucagonemia by variations in blood glucose concentrations. Using fasted R...
متن کاملRegulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors.
Ripglut1;glut2-/- mice have no endogenous glucose transporter type 2 (glut2) gene expression but rescue glucose-regulated insulin secretion. Control of glucagon plasma levels is, however, abnormal, with fed hyperglucagonemia and insensitivity to physiological hypo- or hyperglycemia, indicating that GLUT2-dependent sensors control glucagon secretion. Here, we evaluated whether these sensors were...
متن کاملEvidence of Extrapancreatic Glucagon Secretion in Man.
Glucagon is believed to be a pancreas-specific hormone, and hyperglucagonemia has been shown to contribute significantly to the hyperglycemic state of patients with diabetes. This hyperglucagonemia has been thought to arise from α-cell insensitivity to suppressive effects of glucose and insulin combined with reduced insulin secretion. We hypothesized that postabsorptive hyperglucagonemia repres...
متن کاملErratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585-597.
Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585–597 DOI: 10.2337/db16-er06 Asger Lund, Jonatan I. Bagger, Nicolai J. Wewer Albrechtsen, Mikkel Christensen, Magnus Grøndahl, Bolette Hartmann, Elisabeth R. Mathiesen, Carsten P. Hansen, Jan H. Storkholm, Gerrit van Hall, Jens F. Rehfeld, Daniel Hornburg, Felix Meissner, Matthias Mann, Steen Larsen, Jens J. Hols...
متن کاملResponse of extrapancreatic glucagon to glycemic changes.
Since the secretion of pancreatic glucagon is largely influenced by changes in the blood glucose level, the response of extrapancreatic glucagon to glycemic changes was investigated in man and dogs. Neither insulin-induced hypoglycemia nor arginine infusion caused a rise in plasma glucagon in two patients with total pancreatectomy, but plasma glucagon increased transiently in one of the two pat...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2001
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.50.6.1282